Remarkable Observations in a 7+ Year Advanced Alzheimer’s Case
How 20 months of KineDek AI-CRT sessions produced unexpected systemic improvements—even when brain scans still show structural damage
Picture: Getty ImagesAlzheimer’s disease is a progressive neurodegenerative condition known for its steady decline and devastating impact on cognition, behaviour, and overall function. In advanced stages—especially after seven years—meaningful recovery is rarely seen, and stabilisation itself is uncommon.
This is why one of our long-term Alzheimer’s clients has presented with an outcome that deserves careful attention.
After 20 months of weekly KineDek Brain Bombing sessions, updated brain imaging still shows significant structural damage—expected for this stage of the disease. But her bloodwork now presents as completely normal, showing none of the biochemical indicators commonly associated with advanced neurodegeneration.
This pattern—structural damage with normalised biomarkers—is unusual.
And yet, it aligns with something we’ve observed repeatedly across other chronic-disease cases using KineDek AI-CRT:
-
reduced systemic inflammation
-
normalised metabolic markers
-
improved autonomic balance
-
better mitochondrial resilience
-
and more efficient muscular activation that has whole-body spillover effects
These systemic improvements don’t necessarily reverse structural changes in the brain, but they can dramatically improve cellular environment, mood, and functional capacity.
Early Emotional Shift: “I Feel Happy”
One of the most striking early signals came right after her first ever KineDek session. She spontaneously said:
This emotional brightening continued in subsequent sessions, even as her cognitive abilities remained largely unchanged. For caregivers, this shift alone was a relief—reduced anxiety and improved mood can profoundly improve quality of life in Alzheimer’s.
A Subtle, Unexpected Change in Speech
For nearly the entire 20-month period, there was little to no evidence of cognitive improvement.
However, in the most recent session, we saw a clear change:
-
she used longer and more complete sentences
-
she attempted more complex thoughts
-
at times she struggled to find the words, but the attempt itself was new
This may be a once-off fluctuation—Alzheimer’s can have good days and bad days—but the pattern was sufficiently distinct to merit tracking.
We’ll monitor closely in upcoming sessions.
Understanding the systemic impact of AI-CRT
The most objectively measurable shift is her normal bloodwork, despite advanced structural deterioration in the brain.
In late-stage Alzheimer’s, blood markers often reflect:
-
inflammation
-
metabolic dysfunction
-
oxidative stress
-
neurodegenerative protein breakdown
-
abnormal immune activation
Yet none of these are present now.
This indicates that while the brain structure remains damaged, the systemic disease activity appears dramatically reduced or stabilised.
That’s significant.
Conclusion
Implications of AI-CRTs “Brain-Bombing” Protocol for prevention and early-onset AD
This case suggests a plausible, clinically meaningful pathway by which KineDek’s AI-CRT — through powerful, repeated systemic effects rather than directly repairing visible brain lesions — could slow or reduce the biochemical drivers of Alzheimer’s and therefore help prevent deterioration in early-onset disease. It is not proof of reversal of structural brain damage, but it is exactly the kind of signal that justifies focused clinical trials.
Why this matters?
The AD sufferer's normalised blood biomarkers despite persistent structural damage imply that the downstream, systemic drivers of ongoing neurodegeneration (chronic inflammation, metabolic stress, immune dysregulation, oxidative stress) may have been markedly reduced. That matters because many modern models of Alzheimer’s treat those systemic processes as amplifiers of brain pathology — if you damp them, you can slow further damage and preserve function.
For a deeper discussion on the growing evidence that inflammation and systemic immune dysfunction may be central contributors to Alzheimer’s pathology, see Could an Autoimmune Approach Be the Key to Alzheimer’s?
The Possible Mechanisms Behind These Changes
KineDek AI-CRT creates a unique physiological environment—different from conventional exercise and distinct from passive therapies. Several mechanisms may be contributing to the improvements we see.
1. Myokine Modulation (The “Chi” Analogy)
KineDek sessions stimulate large-scale rhythmic muscle contractions, which trigger the release of myokines—powerful signalling molecules that influence inflammation, metabolism, and even brain function.
Historically, these systemic energy-like effects were described as “chi” in ancient practices like tai chi and qigong. Today, we understand them as biochemical messengers with widespread healing influence.
In Alzheimer’s, myokines like BDNF, irisin, and IL-6 (in its anti-inflammatory mode) may support:
-
reduced neuroinflammation
-
improved metabolic efficiency
-
mood elevation
-
better neural signalling
-
improved sleep–wake cycles
2. Autonomic Nervous System Reset
AI-CRT consistently normalises autonomic balance—reducing sympathetic overdrive and supporting parasympathetic recovery.
For neurodegenerative conditions this can mean:
-
calmer mood
-
better facial affect
-
more stable blood pressure
-
improved digestion
-
clearer speech on good days
3. Improved Lymphatic & Glymphatic Flow
The rhythmic contraction–relaxation pattern of AI-CRT enhances:
-
lymphatic drainage
-
venous return
-
interstitial fluid clearance
This may indirectly support the glymphatic system, which is responsible for clearing metabolic waste from the brain—something that is impaired in Alzheimer’s.
4. Stabilisation of Metabolic Stress
Alzheimer’s has sometimes been called “Type 3 diabetes” because of its metabolic dysfunction. KineDek’s effect on:
-
glucose stability
-
mitochondrial resilience
-
lactate shuttling
-
inflammatory markers
…may help shift the internal environment away from chronic stress and breakdown.
Even if this doesn’t reverse structural brain loss, it can reduce ongoing damage, improve cellular stability, and elevate overall function.
5. Mood Circuits Respond Faster Than Cognitive Circuits
Neural circuits related to emotion and reward can respond to metabolic and systemic improvements long before circuits responsible for memory and language.
This could explain:
-
the immediate “I feel happy”
-
the ongoing positive demeanour
-
the recent, unexpected improvement in sentence formation
Where This Leaves Us
But we are seeing:
-
normalised systemic biomarkers
-
improved mood
-
a possible early sign of speech improvement
-
stabilisation rather than ongoing decline
-
better physiological function than expected at this disease stage
This combination is rare—and worth documenting.
The next few sessions will tell us whether the speech improvement was an isolated good day or the beginning of a new pattern. Either way, the systemic normalisation and the emotional shift alone already represent meaningful gains in quality of life.
